Journal Article

DZNE-2024-00349

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease.

Newton, C. ; Pope, M. ; Rua, C. ; Henson, R. ; Ji, Z. ; Burgess, N. ; Rodgers, C. T. ; Stangl, M. ; Dounavi, M.-E. ; Castegnaro, A. ; Koychev, I. ; Malhotra, P. ; Wolbers, T.DZNE* ; Ritchie, K. ; Ritchie, C. W. ; O'Brien, J. ; Su, L. ; Chan, D. ; Programme, P. D. R. (Collaboration Author)

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.13733

Abstract: Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)-based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD.We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function.Midlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi-risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior-medial EC.Altered PI may represent the transition point from at-risk state to disease manifestation in AD, prior to impairment in other cognitive domains.

Keyword(s): Adult (MeSH) ; Humans (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Entorhinal Cortex: pathology (MeSH) ; Brain: pathology (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Alzheimer's disease ; entorhinal cortex ; path integration ; preclinical ; virtual reality

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Contributing Institute(s):

1. Aging, Cognition and Technology (AG Wolbers)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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