Journal Article

DZNE-2024-00595

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.

Bollack, A. ; Collij, L. E. ; García, D. V. ; Shekari, M. ; Altomare, D. ; Payoux, P. ; Dubois, B. ; Grau-Rivera, O. ; Boada, M. ; Marquié, M. ; Nordberg, A. ; Walker, Z. ; Scheltens, P. ; Schöll, M. ; Wolz, R. ; Schott, J. M. ; Gismondi, R. ; Stephens, A. ; Buckley, C. ; Frisoni, G. B. ; Hanseeuw, B. ; Visser, P. J. ; Vandenberghe, R. ; Drzezga, A.DZNE* ; Yaqub, M. ; Boellaard, R. ; Gispert, J. D. ; Markiewicz, P. ; Cash, D. M. ; Farrar, G. ; Barkhof, F. ; consortium, A. (Collaboration Author)

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.13761

Abstract: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models.Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education.Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.

Keyword(s): Humans (MeSH) ; Male (MeSH) ; Female (MeSH) ; Positron-Emission Tomography (MeSH) ; Aged (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Alzheimer Disease: diagnostic imaging (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Aniline Compounds (MeSH) ; Prognosis (MeSH) ; Middle Aged (MeSH) ; Longitudinal Studies (MeSH) ; Stilbenes (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: metabolism (MeSH) ; Benzothiazoles (MeSH) ; Alzheimer's ; Centiloid ; amyloid ; longitudinal PET ; quantification ; reliable accumulation

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Contributing Institute(s):

1. Positron Emissions Tomography (PET) (AG Boecker)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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