Journal Article

DZNE-2024-01343

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.

Liu, S. ; Park, T. ; Krüger, D. M.DZNE* ; Pena Centeno, T.DZNE* ; Burkhardt, S.DZNE* ; Schutz, A.-L.DZNE* ; Huang, Y.-N. ; Rosewood, T. ; Chaudhuri, S. ; Cho, M. ; Risacher, S. L. ; Wan, Y. ; Shaw, L. M. ; Sananbenesi, F.DZNE* ; Brodsky, A. S. ; Lin, H. ; Krunic, A. ; Blusztajn, J. K. ; Saykin, A. J. ; Delalle, I. ; Fischer, A.DZNE* ; Nho, K. ; Initiative, A. D. N. (Collaboration Author)

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.14230

Abstract: MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis.We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis. Machine learning approaches were applied to investigate the role of miRNAs as blood biomarkers.We identified nine, two, and eight miRNAs significantly associated with A/T/N positivity, respectively. We identified 271 genes targeted by amyloid-related miRNAs with estrogen signaling receptor-mediated signaling among the enriched pathways. Additionally, 220 genes targeted by neurodegeneration-related miRNAs showed enrichment in pathways including the insulin growth factor 1 pathway. The classification performance of demographic information for A/T/N positivity was increased up to 9% with the inclusion of miRNAs.Plasma miRNAs were associated with central A/T/N biomarkers, highlighting their potential as blood biomarkers.We performed association analysis of microRNAs (miRNAs) with amyloid/tau/neurodegeneration (A/T/N) biomarker positivity. We identified dysregulated miRNAs for A/T/N biomarker positivity. We identified Alzheimer's disease biomarker-specific/common pathways related to miRNAs. miRNAs improved the classification for A/T/N positivity by up to 9%. Our study highlights the potential of miRNAs as blood biomarkers.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: blood (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Biomarkers: blood (MeSH) ; MicroRNAs: blood (MeSH) ; MicroRNAs: genetics (MeSH) ; Female (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Machine Learning (MeSH) ; tau Proteins: blood (MeSH) ; Amyloid beta-Peptides: blood (MeSH) ; Alzheimer's disease ; amyloid ; biomarkers ; classification ; microRNAs ; neurodegeneration ; plasma ; tau ; Biomarkers ; MicroRNAs ; tau Proteins ; Amyloid beta-Peptides

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
2. Bioinformatics and Genome Dynamics Core (Göttingen) (Bioinformatics Unit (Göttingen))
3. Genome Dynamics in Neurodegenerative Diseases (AG Sananbenesi)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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