Journal Article

DZNE-2025-00017

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS.

Göschel, L. ; Dell Orco, A.Extern* ; Fillmer, A. ; Aydin, S. ; Ittermann, B. ; Riemann, L. ; Lehmann, S. ; Cano, S. ; Melin, J. ; Pendrill, L. ; Hoede, P. L. ; Teunissen, C. E. ; Schwarz, C. ; Grittner, U. ; Körtvelyessy, P.DZNE* ; Flöel, A. (Last author)DZNE*

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.14318

Abstract: Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer's disease (AD) remain unclear.In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models.Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol.Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively.This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer's disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: blood (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Alzheimer Disease: diagnostic imaging (MeSH) ; tau Proteins: blood (MeSH) ; Female (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Glial Fibrillary Acidic Protein: blood (MeSH) ; Biomarkers: blood (MeSH) ; Magnetic Resonance Spectroscopy (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: pathology (MeSH) ; Amyloid beta-Peptides: blood (MeSH) ; Phosphorylation (MeSH) ; Disease Progression (MeSH) ; Middle Aged (MeSH) ; Neurofilament Proteins: blood (MeSH) ; 7 Tesla ; Alzheimer's disease ; NeuroMET Memory Metric ; amyloid beta 42/40 ; blood‐based biomarkers ; functional magnetic resonance imaging ; glial fibrillary acidic protein ; magnetic resonance imaging ; magnetic resonance spectroscopy ; memory ; mild cognitive impairment ; neurofilament light chain ; plasma biomarkers ; subjective cognitive decline ; tau phosphorylated at threonine 181 ; tau Proteins ; Glial Fibrillary Acidic Protein ; Biomarkers ; Amyloid beta-Peptides ; GFAP protein, human ; Neurofilament Proteins

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Contributing Institute(s):

1. Dementia Prevention – Mechanisms and Clinical Implementation (AG Flöel)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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