Journal Article

DZNE-2025-00406

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The deltoid muscle and the pattern of paresis in ALS.

Ludolph, A. (First author)DZNE* ; Klose, V.DZNE* ; Dreyhaupt, J. ; Del Tredici, K. ; Braak, H.

2025
Steinkopff [Darmstadt]

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Please use a persistent id in citations: doi:10.1007/s00415-025-12949-w

Abstract: There is neuroanatomical and clinical evidence that the corticospinal tract governs the patterns of pareses in sporadic ALS. These patterns are mirrored by phylogenetically young monosynaptic corticomotor neuronal connections. It is well known that, clinically, dysfunction of the deltoid muscle contributes considerably to the early disability of the ALS patient. In this study, we prospectively compared the degree of pareses of the deltoid muscle with the triceps and biceps brachii in N = 71 patients (426 muscles). We could show that the extent of involvement of the deltoid muscle early in the disease process resembles that of the biceps rather than the triceps brachii. This pattern is consistent with functional data of the corticospinal monosynaptic connectivity of all three muscles.

Keyword(s): Humans (MeSH) ; Amyotrophic Lateral Sclerosis: physiopathology (MeSH) ; Amyotrophic Lateral Sclerosis: complications (MeSH) ; Deltoid Muscle: physiopathology (MeSH) ; Deltoid Muscle: pathology (MeSH) ; Male (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Aged (MeSH) ; Paresis: etiology (MeSH) ; Paresis: physiopathology (MeSH) ; Adult (MeSH) ; Prospective Studies (MeSH) ; Muscle, Skeletal: physiopathology (MeSH) ; Pyramidal Tracts: physiopathology (MeSH) ; Pyramidal Tracts: pathology (MeSH) ; Electromyography (MeSH) ; Aged, 80 and over (MeSH) ; Amyotrophic lateral sclerosis ; Biceps ; Corticomotorneuronal ; Deltoid ; Monosynpatic ; Pattern of paresis

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Contributing Institute(s):

1. Clinical Study Center (Ulm) (Clinical Study Center (Ulm))
2. Neuroepidemiology (AG Zhan)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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