Journal Article

DZNE-2025-00706

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation

Liebscher, M. (First author)DZNE* ; Laubacher, C. ; Imhoff-Smith, T. P. ; Birn, R. M. ; Klaus, D. R. ; Frye, C. J. ; Busse, W. W. ; Rosenkranz, M. A.

2025
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.bpsgos.2025.100527

Abstract: Background:Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms.Methods:Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex.Results:Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected p [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, pFDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, pFDR = .010; left: β = 0.23, pFDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, pFDR = .038), which correlated with depressive symptoms.Conclusions:Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection.

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Contributing Institute(s):

1. Brain Resilience (AG Wirth)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; SCOPUS ; Web of Science Core Collection

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