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| Home > Publications Database > Dataset: Mouse CSF analysis of 3, 6, and 12 months old mice in comparison to human CSF |
| Home > Publications Database > Dataset: Mouse CSF analysis of 3, 6, and 12 months old mice in comparison to human CSF |
| Dataset | DZNE-2025-00807 |
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2025
PRoteomics IDEntifications Database
Abstract: Mice are the most commonly used preclinical animal model, but protein analytics of murine cerebrospinal fluid (CSF) remains challenging because of low CSF volume (often <10 µl) and frequent blood contaminations. We developed an improved CSF sampling method that allows routine collection of increased volumes (20-30 µl) of pure CSF from individual mice, enabling multiple protein analytical assays from a single sample. Here, we have analysed the CSF of 3, 6, and 12 months old wild-type mice. Additionally, we collected murine CSF of the same mice at 3 and 6 months of age to compare repeated and single CSF sampling. Furthermore, we analysed human CSF samples as a reference.
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Journal Article
An Improved Method for Sampling and Quantitative Protein Analytics of Cerebrospinal Fluid of Individual Mice.
Molecular & cellular proteomics 24(5), 100958 (2025) [10.1016/j.mcpro.2025.100958]
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