Dataset

DZNE-2025-01190

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Computational Modeling and Validation Data for Trans-spinal Direct Current Stimulation (tsDCS) in SOD1 Mice

de Oliveira Pires, L. ; Wasicki, B. ; Abaei, A. ; Scekic-Zahirovic, J.DZNE* ; roselli, f.DZNE* ; Fernandes, S. R. ; Bączyk, M.

2025
Zenodo

This record in other databases:

Please use a persistent id in citations: doi:10.5281/ZENODO.15348780  doi:10.5281/zenodo.15348780

Abstract: This dataset provides a multimodal collection of data acquired and generated in the context of an investigation that aims to provide a comprehensive computational model that predicts the electric fields (EF) induced by tsDCS intervention in SOD1 mice. It includes a .zip archive for each of the following: Full-body MRI data in DICOM format 3D anatomical models and simulation files related to tsDCS Electrophysiological recordings and analysis scripts validating model predictions 1. Magnetic Resonance Imaging (MRI) Data- Format: DICOM (.dcm)- Modality: MRI, T2-weighted- Acquisition Sequence: FLASH- Anatomical Region: Full-body (mouse)- Slices: 165 axial slices- Includes README file with more detailed information 2. Computational Simulation & Anatomical Models - Formats: >*.mph and .mphtxt COMSOL model files (mesh and simulation setup) > STL-format 3D anatomical models for computational modeling - Anatomical Structures in STL Files: > Heart, Intestines, Kidneys, Liver, Lungs, Pancreas, Spleen, Stomach > Skull and Brain > Full spine (including GM, WM, CSF, dura mater, vertebrae, IVDs, and surrounding fat) - Includes README file with more detailed information 3. Electrophysiological Validation Data - Formats: > Spike Recordings (.smr): Raw electrophysiological recordings (openable in Spike2) > RStudio Script (.R): For statistical analysis and visualization of electrophysiological results > Voltage Deflection Measurements (.xlsx): Tabulated results of evoked voltage by electrode distance, depth, tsDCS configuration, and current intensity

Keyword(s): computational model ; spinal cord ; amyotrophic lateral sclerosis ; in vivo ; electrophysiology ; magnetic resonance imaging ; mice

---

Contributing Institute(s):

1. Metabolic Changes in Neurodegeneration (AG Roselli)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2025

---

---

Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article de Oliveira Pires, L. ; Wasicki, B. ; Abaei, A. ; Scekic-Zahirovic, J.DZNE* ; Roselli, F.DZNE* ; Fernandes, S. ; Bączyk, M.
A computational model of tsDCS effects in SOD1 mice: from MRI-based design to validation.
Computers in biology and medicine 197(Pt B), 111082 (2025) [10.1016/j.compbiomed.2025.111082]2025   Files BibTeX | EndNote: XML, Text | RIS

---