Journal Article

DZNE-2025-01241

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.

Parveen, K. ; Ross, J. A. ; van der Wurp, H. ; Balzer-Geldsetzer, M. ; Berg, D. ; Deuschl, G. ; Gasser, T.DZNE* ; Hilker-Roggendorf, R. ; Kalbe, E. ; Liepelt-Scarfone, I.DZNE* ; Mollenhauer, B.Extern* ; Riedel, O. ; Röske, S.DZNE* ; Schulz, J. B. ; Spottke, A.DZNE* ; Storch, A.DZNE* ; Trenkwalder, C. ; Kassubek, J.DZNE* ; Witt, K. ; Dodel, R. ; Wüllner, U.DZNE* ; Ramirez, A.DZNE* ; Dalmasso, M. C.

2025
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.1177/1877718X251356512

Abstract: Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.

Keyword(s): Humans (MeSH) ; Parkinson Disease: genetics (MeSH) ; Parkinson Disease: complications (MeSH) ; Genome-Wide Association Study (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Female (MeSH) ; Disease Progression (MeSH) ; Cognitive Dysfunction: genetics (MeSH) ; Cognitive Dysfunction: etiology (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Dementia: genetics (MeSH) ; Dementia: etiology (MeSH) ; Middle Aged (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Multifactorial Inheritance (MeSH) ; Alzheimer's disease ; Parkinson's disease ; genome-wide association study ; mild cognitive impairment ; single nucleotide polymorphism

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)
2. Neuropsychology (AG Wagner)
3. Clinical Research Platform (CRP) (AG Spottke)
4. Clinical Research Platform (CRP) (Clinical Research Platform (CRP))
5. Non-Motor Symptoms in Parkinson's disease (AG Storch)
6. Clinical Study Center (Ulm) (Clinical Study Center (Ulm))
7. Biomarker Parkinson's Disease (AG Wüllner)
8. Patient Studies (Bonn) (Patient Studies (Bonn))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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