Journal Article

DZNE-2026-00186

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mitochondrial specialization and signaling shape neuronal function.

Tong, B. C. ; Gubinelli, F.Extern* ; Burbulla, L. F.DZNE* ; Harbauer, A. B.

2026
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.tins.2025.12.006

Abstract: Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need for long-range transport and local polarization mechanisms. In addition, action potential firing and restoration of ionic gradients, as well as dynamic changes in synaptic plasticity, further increase the energetic demands of neurons. In this review, we highlight the roles mitochondria play in vertebrate neuronal biology and how mitochondrial functionality is tuned to support the unique demands of neurons. We cover the influence of mitochondrial positioning, ATP generation and Ca2+ buffering on neuronal function, and explore the role of mitochondria in neurotransmitter metabolism and local protein translation.

Keyword(s): Mitochondria: physiology (MeSH) ; Mitochondria: metabolism (MeSH) ; Animals (MeSH) ; Neurons: physiology (MeSH) ; Neurons: metabolism (MeSH) ; Humans (MeSH) ; Signal Transduction: physiology (MeSH) ; Neuronal Plasticity: physiology (MeSH) ; Calcium: metabolism (MeSH) ; Ca(2+) signaling ; local translation ; neuronal cell biology ; neurotransmitter metabolism ; respiration ; transport ; Calcium

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Contributing Institute(s):

1. Translational Disease Modeling (AG Burbulla)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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