Journal Article

DZNE-2020-06222

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

Benito, E. (First author)DZNE* ; Kerimoglu, C.DZNE* ; Ramachandran, B. ; Pena Centeno, T.DZNE* ; Jain, G.DZNE* ; Stilling, R. M.DZNE* ; Islam, R.DZNE* ; Capece, V.DZNE* ; Zhou, Q.DZNE* ; Edbauer, D.DZNE* ; Dean, C. ; Fischer, A. (Last author)DZNE*

2018
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2018.03.059

Abstract: Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.

Keyword(s): Animals (MeSH) ; Behavior, Animal (MeSH) ; Brain: metabolism (MeSH) ; Cognition: physiology (MeSH) ; Excitatory Postsynaptic Potentials (MeSH) ; Hippocampus: physiology (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; MicroRNAs: chemistry (MeSH) ; MicroRNAs: metabolism (MeSH) ; Neuronal Plasticity: physiology (MeSH) ; Physical Conditioning, Animal (MeSH) ; RNA: chemistry (MeSH) ; RNA: isolation & purification (MeSH) ; RNA: metabolism (MeSH) ; Sequence Analysis, RNA (MeSH) ; Social Environment (MeSH) ; Spermatozoa: metabolism (MeSH) ; MIRN132 microRNA, rat ; MIRN212 microRNA, rat ; MicroRNAs ; RNA

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
2. Cell Biology of Neurodegeneration (AG Edbauer)
3. Bioinformatics and Genome Dynamics Core (Bioinformatics and Genome Dynamics Core)
4. Göttingen common (Göttingen common)
5. Computational Systems Biology (AG Bonn 2)
6. Adaptive Immunity in Neurodegeneration (AG Zhou)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2018

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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