Abstract/Journal Article

DZNE-2020-00617

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Development of a human reporter stem cell line for mature cones in retinal organoids

Wieneke, S.DZNE* ; Karl, M. O. (Last author)DZNE*

2018

Abstract: Purpose : Much of our knowledge about photoreceptor development comes from the mouse retina that is rich in rods but has significantly lower amount of cones. The derivation of three-dimensional (3D) retinal organoids from human stem cells allowed us to study differentiation of human photoreceptors. Therefore, our aim was to develop a fluorescent reporter human induced pluripotent stem cell (hiPSC) line that would allow identification and isolation of postmitotic cones from 3D retinas and further transcriptomic analysis.

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Contributing Institute(s):

1. Cell Culture Platform (Cell Culture Platform)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2018

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Database coverage:
; ; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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