Journal Article

DZNE-2020-01431

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Liu, K. Y. (Corresponding author) ; Kievit, R. A. ; Tsvetanov, K. A. ; Betts, M. J.DZNE* ; Düzel, E.DZNE* ; Rowe, J. B. ; Howard, R. ; Hämmerer, D. (Last author)DZNE*

2020
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-020-15410-w

Abstract: The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.

Keyword(s): Adolescent (MeSH) ; Adrenergic Neurons: physiology (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Aging: genetics (MeSH) ; Aging: physiology (MeSH) ; Behavior: physiology (MeSH) ; Biobehavioral Sciences (MeSH) ; Cognition: physiology (MeSH) ; Cognitive Aging: physiology (MeSH) ; Cohort Studies (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Latent Class Analysis (MeSH) ; Locus Coeruleus: diagnostic imaging (MeSH) ; Locus Coeruleus: physiology (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Magnetoencephalography (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neurodegenerative Diseases: genetics (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)
2. Linking imaging projects iNET (AG Speck)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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