Journal Article

DZNE-2022-00053

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.

Frank, A. (First author)DZNE* ; Bendig, J. ; Schniewind, I.Extern* ; Polanski, W. H. ; Sobottka, S. B. ; Reichmann, H. ; Akgün, K. ; Ziemssen, T. ; Klingelhoefer, L. ; Falkenburger, B. H. (Last author)DZNE*

2022
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41598-022-05117-x

Abstract: Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson's disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.

Keyword(s): Aged (MeSH) ; Deep Brain Stimulation: adverse effects (MeSH) ; Deep Brain Stimulation: methods (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neurofilament Proteins: blood (MeSH) ; Neurons: pathology (MeSH) ; Neurosurgical Procedures: adverse effects (MeSH) ; Parkinson Disease: therapy (MeSH) ; Subthalamic Nucleus: cytology (MeSH) ; Subthalamic Nucleus: pathology (MeSH) ; Subthalamic Nucleus: surgery (MeSH) ; Neurofilament Proteins ; neurofilament protein L

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Contributing Institute(s):

1. Clinical Study Team Dresden (Clinical Study Team Dresden ; AG Falkenburger)
2. Dresden common (Dresden common)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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