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| Home > Publications Database > Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. |
| Home > Publications Database > Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. |
| Journal Article | DZNE-2022-00644 |
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2023
Wiley
Hoboken, NJ
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Please use a persistent id in citations: doi:10.1002/alz.12674
Abstract: It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of the initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum.Cross-sectional and longitudinal data from the multicenter, memory clinic-based DELCODE study.The SCD group showed slightly worse cognition as well as more subtle functional and behavioral symptoms than the control group (CO). SCD-A+ cases (39.3% of all SCD) showed greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms than CO-A+. Amyloid concentration in the CSF had a greater effect on longitudinal cognitive decline in SCD than in the CO group.Our data suggests that SCD serves the identification of stage 2 of the AD continuum and that stage 2, operationalized as SCD-A+, is associated with subtle, but extended impact of AD pathology in terms of neurodegeneration, symptoms and clinical progression.
Keyword(s): Humans (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Amyloid beta-Peptides (MeSH) ; Cross-Sectional Studies (MeSH) ; Cognitive Dysfunction: diagnosis (MeSH) ; Cognition (MeSH) ; Biomarkers (MeSH) ; tau Proteins (MeSH) ; Alzheimer's disease ; amyloid beta 42 ; apolipoprotein E ; cerebrospinal fluid ; longitudinal ; magnetic resonance imaging ; mild cognitive impairment ; positron emission tomography ; subjective cognitive decline ; tau
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