Journal Article (Review Article)

DZNE-2023-00141

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Epigenetic aging in adult neurogenesis.

Zocher, S. (First author)DZNE* ; Toda, T. (Last author)DZNE*

2023
Wiley New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/hipo.23494

Abstract: Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age-related impairments in NSC activity underlie this reduction. Particularly, increased NSC quiescence and consequently reduced NSC proliferation are considered to be major drivers of the low neurogenesis levels in the aged brain. Epigenetic regulators control the gene expression programs underlying NSC quiescence, proliferation and differentiation and are hence critical to the regulation of adult neurogenesis. Epigenetic alterations have also emerged as central hallmarks of aging, and recent studies suggest the deterioration of the NSC-specific epigenetic landscape as a driver of the age-dependent decline in adult neurogenesis. In this review, we summarize the recently accumulating evidence for a role of epigenetic dysregulation in NSC aging and propose perspectives for future research directions.

Keyword(s): Neurogenesis: physiology (MeSH) ; Cell Differentiation: genetics (MeSH) ; Neurons: metabolism (MeSH) ; Hippocampus: physiology (MeSH) ; Epigenesis, Genetic (MeSH) ; DNA methylation ; Lamin B1 ; aging ; chromatin ; epigenetic ; hippocampus ; histone ; neural stem cells ; neurogenesis

Note: Funding information: Deutsche Forschungsgemeinschaft, Grant/Award Numbers: TO1347/4-1, TO1347/3-1; H2020 European Research Council, Grant/Award Numbers: EAGER, 804468

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Contributing Institute(s):

1. Nuclear Architecture in Neural Plasticity and Aging (AG Toda)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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