Journal Article

DZNE-2023-00363

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb.

Li, K. ; Figarella, K. ; Su, X. ; Kovalchuk, Y. ; Gorzolka, J. ; Neher, J. J.DZNE* ; Mojtahedi, N. ; Casadei, N. ; Hedrich, U. B. S. ; Garaschuk, O.

2023
Springer International Publishing AG Cham (ZG)

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Please use a persistent id in citations: doi:10.1007/s00018-023-04753-4

Abstract: The development and survival of adult-born neurons are believed to be driven by sensory signaling. Here, in vivo analyses of motility, morphology and Ca2+ signaling, as well as transcriptome analyses of adult-born juxtaglomerular cells with reduced endogenous excitability (via cell-specific overexpression of either Kv1.2 or Kir2.1 K+ channels), revealed a pronounced impairment of migration, morphogenesis, survival, and functional integration of these cells into the mouse olfactory bulb, accompanied by a reduction in cytosolic Ca2+ fluctuations, phosphorylation of CREB and pCREB-mediated gene expression. Moreover, K+ channel overexpression strongly downregulated genes involved in neuronal migration, differentiation, and morphogenesis and upregulated apoptosis-related genes, thus locking adult-born cells in an immature and vulnerable state. Surprisingly, cells deprived of sensory-driven activity developed normally. Together, the data reveal signaling pathways connecting the endogenous intermittent neuronal activity/Ca2+ fluctuations as well as enhanced Kv1.2/Kir2.1 K+ channel function to migration, maturation, and survival of adult-born neurons.

Keyword(s): Mice (MeSH) ; Animals (MeSH) ; Olfactory Bulb: metabolism (MeSH) ; Neurons: metabolism (MeSH) ; Neurogenesis: genetics (MeSH) ; Cell Differentiation (MeSH) ; Cell Movement (MeSH) ; Adult neurogenesis ; Differentiation ; Endogenous activity ; Migration ; Neuronal development ; Olfactory bulb ; Potassium channels ; Spontaneous calcium transients ; Survival ; pCREB

Note: CC BY

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Contributing Institute(s):

1. Neuroimmunology and Neurodegenerative Disease (AG Neher)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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