Journal Article

DZNE-2023-00472

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial.

Dafsari, F. S. ; Bewernick, B. ; Böhringer, S. ; Domschke, K. ; Elsaesser, M. ; Löbner, M. ; Luppa, M. ; Preis, L.Extern* ; Püsken, J. ; Schmitt, S. ; Szekely, A.-J. ; Hellmich, M. ; Müller, W. ; Wagner, M.Extern* ; Peters, O.Extern* ; Frölich, L.Extern* ; Riedel-Heller, S. ; Schramm, E. ; Hautzinger, M. ; Jessen, F. (Last author)DZNE*

2023
Karger Basel

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Please use a persistent id in citations: doi:10.1159/000529445

Abstract: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare.The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting.In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up.Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: -1.01 [95% CI: -2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms.Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.

Keyword(s): Humans (MeSH) ; Aged (MeSH) ; Depression: therapy (MeSH) ; Depression: psychology (MeSH) ; Quality of Life (MeSH) ; Treatment Outcome (MeSH) ; Cognitive Behavioral Therapy: methods (MeSH) ; Depressive Disorder: therapy (MeSH) ; Cognitive behavioral therapy ; Geriatric depression ; Late-life depression ; Randomized controlled trial ; Supportive psychotherapy

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Contributing Institute(s):

1. Patient Studies Cologne (AG Jessen)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 20 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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