Journal Article

DZNE-2023-00486

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png New insights into the autophagy-NAD axis in brain disease.

Perez, M. J. (First author)DZNE* ; Deleidi, M.Extern*

2023
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2023.112420

Abstract: Sun et al. demonstrate that defects in autophagy cause nicotinamide adenine dinucleotide (NAD) depletion and neurotoxicity.1 Restoring NAD levels rescues cytotoxicity in autophagy-deficient neurons, providing a potential therapy for neurodegenerative and lysosomal storage diseases associated with autophagy defects.

Keyword(s): Humans (MeSH) ; NAD (MeSH) ; Brain Diseases (MeSH) ; Neurons (MeSH) ; Autophagy (MeSH) ; CP: Cell biology ; CP: Metabolism ; NAD

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Contributing Institute(s):

1. Mitochondria and Inflammation in Neurodegenerative Diseases (AG Deleidi)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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