Journal Article

DZNE-2024-00061

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline.

Teipel, S. (First author)DZNE* ; Dyrba, M.DZNE* ; Kleineidam, L.DZNE* ; Brosseron, F.DZNE* ; Levin, F.DZNE* ; Bruno, D. ; Buerger, K.DZNE* ; Cosma, N. ; Schneider, L.-S. ; Düzel, E.DZNE* ; Glanz, W.DZNE* ; Fliessbach, K.DZNE* ; Janowitz, D.Extern* ; Kilimann, I.DZNE* ; Laske, C.DZNE* ; Munk, M. H.DZNE* ; Maier, F. ; Peters, O.DZNE* ; Pomara, N. ; Perneczky, R.DZNE* ; Rauchmann, B. S.Extern* ; Priller, J.DZNE* ; Ramirez, A.DZNE* ; Roy, N.DZNE* ; Schneider, A.DZNE* ; Spottke, A.DZNE* ; Spruth, E. J.DZNE* ; Roeske, S.DZNE* ; Wagner, M.DZNE* ; Wiltfang, J.DZNE* ; Wolfsgruber, S.DZNE* ; Bartels, C.Extern* ; Jessen, F.DZNE* ; Heneka, M. T. (Last author)DZNE* ; group, D. s. ; Initiative, t. A. D. N. (Collaboration Author)

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/dad2.12510

Abstract: We investigated the association of inflammatory mechanisms with markers of Alzheimer's disease (AD) pathology and rates of cognitive decline in the AD spectrum.We studied 296 cases from the Deutsches Zentrum für Neurodegenerative Erkrankungen Longitudinal Cognitive Impairment and Dementia Study (DELCODE) cohort, and an extension cohort of 276 cases of the Alzheimer's Disease Neuroimaging Initiative study. Using Bayesian confirmatory factor analysis, we constructed latent factors for synaptic integrity, microglia, cerebrovascular endothelial function, cytokine/chemokine, and complement components of the inflammatory response using a set of inflammatory markers in cerebrospinal fluid.We found strong evidence for an association of synaptic integrity, microglia response, and cerebrovascular endothelial function with a latent factor of AD pathology and with rates of cognitive decline. We found evidence against an association of complement and cytokine/chemokine factors with AD pathology and rates of cognitive decline.Latent factors provided access to directly unobservable components of the neuroinflammatory response and their association with AD pathology and cognitive decline.

Keyword(s): amyloid ; chemokine factors ; complement ; endothelial function ; microglia ; structural equation models ; tau

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Contributing Institute(s):

1. Neuroinflammation, Biomarker (AG Heneka ; AG Heneka)
2. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
3. Neuropsychology (AG Wagner)
4. Clinical Research (Munich) (Clinical Research (Munich))
5. Clinical Neurophysiology and Memory (AG Düzel)
6. Patient Studies Bonn (Patient Studies Bonn)
7. Parkinson Genetics (AG Gasser)
8. Biomarker-Assisted Early Detection of Dementias (AG Peters)
9. Translational Neuropsychiatry (AG Priller)
10. Molecular Neurobiology (AG Simons)
11. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)
12. Clinical Research (Bonn) (AG Spottke)
13. Translational Dementia Research (Bonn) (AG Schneider)
14. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)
15. Clinical Alzheimer’s Disease Research (AG Jessen)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Experiment(s):

1. Longitudinal Cognitive Impairment and Dementia Study

Appears in the scientific report 2024

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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