Journal Article

DZNE-2024-00242

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation.

Toda, T. (First author)DZNE* ; Bedrosian, T. A. ; Schafer, S. T. ; Cuoco, M. S. ; Linker, S. B. ; Ghassemzadeh, S. ; Mitchell, L. ; Whiteley, J. T. ; Novaresi, N. ; McDonald, A. H. ; Gallina, I. S. ; Yoon, H. ; Hester, M. E. ; Pena, M. ; Lim, C. ; Suljic, E. ; AlFatah Mansour, A. ; Boulard, M. ; Parylak, S. L. ; Gage, F. H.

2024
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2024.113774

Abstract: Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

Keyword(s): Humans (MeSH) ; Animals (MeSH) ; Mice (MeSH) ; Cell Differentiation (MeSH) ; Genomic Instability (MeSH) ; Long Interspersed Nucleotide Elements (MeSH) ; Neural Stem Cells (MeSH) ; CP: Developmental biology ; CP: Neuroscience ; L1 ; LINE-1 ; brain development ; neural progenitor cells ; repetitive elements

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Contributing Institute(s):

1. Nuclear Architecture in Neural Plasticity and Aging (AG Toda)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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