Journal Article (Review Article)

DZNE-2025-01364

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Neuroprotective therapies for neonatal hypoxic-ischemic brain injury - a contemporary update.

Sabir, H. (Last author)DZNE*

2025
Saunders Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1016/j.semperi.2025.152128

Abstract: Neonatal encephalopathy of hypoxic-ischemic origin remains a leading cause of global neonatal mortality. Over the past decades, various neuroprotective strategies have been explored; however, therapeutic hypothermia remains the only clinically approved intervention to date. This review outlines emerging and adjunctive treatment modalities beyond therapeutic hypothermia and emphasizes the critical need for robust and reproducible translational research to bridge the gap between preclinical findings and clinical applications.

Keyword(s): Humans (MeSH) ; Hypoxia-Ischemia, Brain: therapy (MeSH) ; Infant, Newborn (MeSH) ; Hypothermia, Induced: methods (MeSH) ; Neuroprotective Agents: therapeutic use (MeSH) ; Neuroprotection (MeSH) ; Asphyxia Neonatorum: therapy (MeSH) ; Asphyxia Neonatorum: complications (MeSH) ; Hypoxic-ischemic encephalopathy (HIE) ; Neuroprotection ; Newborn ; Neuroprotective Agents

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Contributing Institute(s):

1. Neonatal Neuroscience (AG Sabir)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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