Journal Article (Review Article)

DZNE-2020-03245

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Activation and regulation of the inflammasomes.

Latz, E. (First author)DZNE* ; Xiao, T. S. ; Stutz, A.

2013
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/nri3452

Abstract: Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.

Keyword(s): Autophagy: immunology (MeSH) ; Carrier Proteins: immunology (MeSH) ; Carrier Proteins: metabolism (MeSH) ; Humans (MeSH) ; Inflammasomes: immunology (MeSH) ; Inflammasomes: metabolism (MeSH) ; Inflammation Mediators: immunology (MeSH) ; Inflammation Mediators: metabolism (MeSH) ; Interleukin-18: immunology (MeSH) ; Interleukin-18: metabolism (MeSH) ; Interleukin-1beta: immunology (MeSH) ; Interleukin-1beta: metabolism (MeSH) ; Models, Immunological (MeSH) ; NLR Family, Pyrin Domain-Containing 3 Protein (MeSH) ; Receptors, Interleukin-1: immunology (MeSH) ; Receptors, Interleukin-1: metabolism (MeSH) ; Signal Transduction: immunology (MeSH) ; Carrier Proteins ; Inflammasomes ; Inflammation Mediators ; Interleukin-18 ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Receptors, Interleukin-1

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2013

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 40 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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