Journal Article

DZNE-2024-01193

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Blood-derived microRNAs are related to cognitive domains in the general population.

Melas, K. (First author)DZNE* ; Talevi, V.DZNE* ; Imtiaz, M. A.DZNE* ; Etteldorf, R.DZNE* ; Estrada, S.DZNE* ; Krüger, D. M.DZNE* ; Pena-Centeno, T.DZNE* ; Aziz, N. A.DZNE* ; Fischer, A.DZNE* ; Breteler, M. M. B. (Last author)DZNE*

2024
Wiley Hoboken, NJ

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/alz.14197

Abstract: Blood-derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings and identification of novel miRNAs associated with cognitive domains, including their relation to brain structure and the pathways they regulate, are still lacking.We examined blood-derived miRNAs and miRNA co-expression clusters in relation to cognitive domains, structural magnetic resonance imaging measures, target gene expression, and genetic variants in 2869 participants of a population-based cohort.Five previously identified and 14 novel miRNAs were associated with cognitive domains. Eleven of these were also associated with cortical thickness and two with hippocampal volume. Multi-omics analysis showed that certain identified miRNAs were genetically influenced and regulated genes in pathways like neurogenesis and synapse assembly.We identified miRNAs associated with cognitive domains, brain regions, and neuronal processes affected by aging and neurodegeneration, making them promising candidate blood-based biomarkers or therapeutic targets of subclinical cognitive dysfunction.We investigated the association of blood-derived microRNAs with cognitive domains. Five previously identified and 14 novel microRNAs were associated with cognition. Eleven cognition-related microRNAs were also associated with cortical thickness. Identified microRNAs were linked to genes associated with neuronal functions. Results provide putative biomarkers or therapeutic targets of cognitive aging.

Keyword(s): Humans (MeSH) ; MicroRNAs: genetics (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Cognitive Dysfunction: genetics (MeSH) ; Cognition: physiology (MeSH) ; Brain (MeSH) ; Cohort Studies (MeSH) ; Middle Aged (MeSH) ; Biomarkers: blood (MeSH) ; Hippocampus: pathology (MeSH) ; biomarker ; cognition ; cortical thickness ; miR‐10401‐3p ; miR‐125b‐5p ; miR‐128‐3p ; miR‐134‐5p ; miR‐192‐5p ; miR‐215‐5p ; miR‐4677‐5p ; miR‐4732‐3p ; miR‐92a‐3p ; miR‐92b‐3p ; microRNA ; population‐based

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler)
2. Population & Clinical Neuroepidemiology (AG Aziz)
3. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
4. Bioinformatics and Genome Dynamics Core (Göttingen) (Bioinformatics Unit (Göttingen))

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)
3. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. Rhineland Study / Bonn

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Preprint Melas, K. (First author)DZNE* ; Talevi, V.DZNE* ; Etteldorf, R.DZNE* ; Estrada, S.DZNE* ; Krüger, D. M.DZNE* ; Pena, T.DZNE* ; Aziz, N. A.DZNE* ; Fischer, A.DZNE* ; Breteler, M. (Last author)DZNE*
Circulating microRNAs are related to cognitive domains in the general population
[10.1101/2024.05.07.24306994] BibTeX | EndNote: XML, Text | RIS

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