Journal Article

DZNE-2021-00219

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Schulte-Schrepping, J. ; Reusch, N. ; Paclik, D. ; Baßler, K. ; Schlickeiser, S. ; Zhang, B. ; Krämer, B. ; Krammer, T. ; Brumhard, S. ; Bonaguro, L. ; De Domenico, E.DZNE* ; Wendisch, D. ; Grasshoff, M. ; Kapellos, T. S. ; Beckstette, M. ; Pecht, T. ; Saglam, A.DZNE* ; Dietrich, O. ; Mei, H. E. ; Schulz, A. R. ; Conrad, C. ; Kunkel, D. ; Vafadarnejad, E. ; Xu, C.-J. ; Horne, A. ; Herbert, M. ; Drews, A.DZNE* ; Thibeault, C. ; Pfeiffer, M. ; Hippenstiel, S. ; Hocke, A. ; Müller-Redetzky, H. ; Heim, K.-M. ; Machleidt, F. ; Uhrig, A. ; Bosquillon de Jarcy, L. ; Jürgens, L. ; Stegemann, M. ; Glösenkamp, C. R. ; Volk, H.-D. ; Goffinet, C. ; Landthaler, M. ; Wyler, E. ; Georg, P. ; Schneider, M. ; Dang-Heine, C. ; Neuwinger, N. ; Kappert, K. ; Tauber, R. ; Corman, V. ; Raabe, J. ; Kaiser, K. M. ; Vinh, M. T. ; Rieke, G. ; Meisel, C. ; Ulas, T. ; Becker, M. ; Geffers, R. ; Witzenrath, M. ; Drosten, C. ; Suttorp, N. ; von Kalle, C. ; Kurth, F. ; Händler, K. ; Schultze, J. L.DZNE* ; Aschenbrenner, A. C. ; Li, Y. ; Nattermann, J. ; Sawitzki, B. ; Saliba, A.-E. ; Sander, L. E. ; Initiative, D. C. O. (Collaboration Author) ; Angelov, A. ; Bals, R. ; Bartholomäus, A. ; Becker, A. ; Bezdan, D. ; Bonifacio, E. ; Bork, P. ; Clavel, T. ; Colome-Tatche, M. ; Diefenbach, A. ; Dilthey, A. ; Fischer, N. ; Förstner, K. ; Frick, J.-S. ; Gagneur, J. ; Goesmann, A. ; Hain, T. ; Hummel, M. ; Janssen, S. ; Kalinowski, J. ; Kallies, R. ; Kehr, B. ; Keller, A. ; Kim-Hellmuth, S. ; Klein, C. ; Kohlbacher, O. ; Korbel, J. O. ; Kurth, I. ; Landthaler, M. ; Li, Y. ; Ludwig, K. ; Makarewicz, O. ; Marz, M. ; McHardy, A. ; Mertes, C. ; Nöthen, M.DZNE* ; Nürnberg, P. ; Ohler, U. ; Ossowski, S. ; Overmann, J. ; Peter, S. ; Pfeffer, K. ; Poetsch, A. R. ; Pühler, A. ; Rajewsky, N. ; Ralser, M. ; Rieß, O. ; Ripke, S. ; Nunes da Rocha, U. ; Rosenstiel, P. ; Saliba, A.-E. ; Sander, L. E. ; Sawitzki, B. ; Schiffer, P. ; Schulte, E.-C. ; Sczyrba, A. ; Stegle, O. ; Stoye, J. ; Theis, F. ; Vehreschild, J. ; Vogel, J. ; von Kleist, M. ; Walker, A. ; Walter, J. ; Wieczorek, D. ; Ziebuhr, J.

2020
Elsevier New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.cell.2020.08.001

Abstract: Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; CD11 Antigens: genetics (MeSH) ; CD11 Antigens: metabolism (MeSH) ; COVID-19 (MeSH) ; Cells, Cultured (MeSH) ; Coronavirus Infections: blood (MeSH) ; Coronavirus Infections: immunology (MeSH) ; Coronavirus Infections: pathology (MeSH) ; Female (MeSH) ; HLA-DR Antigens: genetics (MeSH) ; HLA-DR Antigens: metabolism (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Myeloid Cells: cytology (MeSH) ; Myeloid Cells: immunology (MeSH) ; Myelopoiesis (MeSH) ; Pandemics (MeSH) ; Pneumonia, Viral: blood (MeSH) ; Pneumonia, Viral: immunology (MeSH) ; Pneumonia, Viral: pathology (MeSH) ; Proteome: genetics (MeSH) ; Proteome: metabolism (MeSH) ; Proteomics (MeSH) ; Single-Cell Analysis (MeSH) ; COVID-19 ; SARS-CoV-2 ; dysfunctional neutrophils ; emergency myelopoiesis ; immune profiling ; mass cytometry ; monocytes ; neutrophils ; scRNA-seq ; CD11 Antigens ; HLA-DR Antigens ; Proteome

Note: ISSN 0092-8674 not unique: **3 hits**.

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Contributing Institute(s):

1. Platform for Single Cell Genomics and Epigenomics (Schultze - PRECISE)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 60 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset Schultze, J.DZNE* ; de Domenico, E.DZNE* ; Saglam, A.DZNE* ; Drews, A.-D.DZNE* ; Ulas, T.DZNE* ; Becker, M. K. H.DZNE* ; Händler, K.DZNE*
Dataset: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Human Cell Atlas Data Explorer (2025)2025   Fulltext BibTeX | EndNote: XML, Text | RIS

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