Journal Article

DZNE-2021-01132

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Synchronous activity patterns in the dentate gyrus during immobility.

Pofahl, M.Extern* ; Nikbakht, N. ; Haubrich, A.Extern* ; Nguyen, T. ; Masala, N. ; Distler, F. ; Braganza, O. ; Macke, J. H. ; Ewell, L. A. ; Golcuk, K. ; Beck, H. (Last author)DZNE*

2021
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: doi:10.7554/eLife.65786

Abstract: The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in vivo two-photon Ca2+ imaging, we show that in immobile mice dentate granule cells generate sparse, synchronized activity patterns associated with entorhinal cortex activation. These population events are structured and modified by changes in the environment; and they incorporate place- and speed cells. Importantly, they are more similar than expected by chance to population patterns evoked during self-motion. Using optogenetic inhibition, we show that granule cell activity is not only required during exploration, but also during immobility in order to form dentate gyrus-dependent spatial memories.

Keyword(s): Animals (MeSH) ; Dentate Gyrus: physiology (MeSH) ; Female (MeSH) ; Immobilization (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Neuroimaging (MeSH) ; Neurons: physiology (MeSH) ; Optogenetics (MeSH) ; dentate gyrus ; hippocampus ; learning & memory ; mouse ; neuroscience ; pattern separation

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Contributing Institute(s):

1. Bonn common (Bonn common)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2021

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