Journal Article

DZNE-2022-01585

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults.

Boettcher, A. (First author)DZNE* ; Zarucha, A.DZNE* ; Koebe, T.DZNE* ; Gaubert, M.DZNE* ; Höppner, A.DZNE* ; Altenstein, S.DZNE* ; Bartels, C.Extern* ; Bürger, K.DZNE* ; Dechent, P. ; Dobisch, L.DZNE* ; Ewers, M.DZNE* ; Fliessbach, K.DZNE* ; Freiesleben, S. D.Extern* ; Frommann, I.DZNE* ; Haynes, J. D. ; Janowitz, D. ; Kilimann, I.DZNE* ; Kleineidam, L.DZNE* ; Laske, C.DZNE* ; Maier, F. ; Metzger, C.DZNE* ; Munk, M. H. J.DZNE* ; Perneczky, R.DZNE* ; Peters, O.DZNE* ; Priller, J.DZNE* ; Rauchmann, B.-S.Extern* ; Roy, N.DZNE* ; Scheffler, K. ; Schneider, A.DZNE* ; Spottke, A.DZNE* ; Teipel, S. J.DZNE* ; Wiltfang, J.DZNE* ; Wolfsgruber, S.DZNE* ; Yakupov, R.DZNE* ; Düzel, E.DZNE* ; Jessen, F.DZNE* ; Röske, S.DZNE* ; Wagner, M.DZNE* ; Kempermann, G.DZNE* ; Wirth, M. (Last author)DZNE*

2022
Frontiers Research Foundation Lausanne

This record in other databases:    

Please use a persistent id in citations: doi:10.3389/fpsyg.2022.945709

Abstract: Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer's disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (n = 70) were compared to controls without a history of musical instrument playing (n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion.

Keyword(s): brain aging ; brain plasticity ; cognitive reserve ; instrument playing ; prevention ; resilience

Note: CC BY: https://creativecommons.org/licenses/by/4.0/

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Contributing Institute(s):

1. Brain Resilience (AG Wirth)
2. Clinical Planning and Intersite Group (AG Donix)
3. Zentrales Personal und Resourcen (Central Personnel and Resources)
4. Interdisciplinary Dementia Research (AG Endres)
5. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)
6. Molecular Neurobiology (AG Simons)
7. Patient Studies Bonn (Patient Studies Bonn)
8. Neuropsychology (AG Wagner)
9. Parkinson Genetics (AG Gasser)
10. Translational Neuropsychiatry (AG Priller)
11. Clinical Research Platform (CRP) (Clinical Research Platform (CRP))
12. Translational Dementia Research (Bonn) (AG Schneider)
13. Clinical Neurophysiology and Memory (AG Düzel)
14. Patient Studies (AG Klockgether)
15. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
16. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)
17. Clinical Alzheimer’s Disease Research (AG Jessen)
18. Adult Neurogenesis (AG Kempermann)
19. Delcode (Delcode)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 351 - Brain Function (POF4-351) (POF4-351)
3. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Experiment(s):

1. Longitudinal Cognitive Impairment and Dementia Study

Appears in the scientific report 2022

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; SCOPUS ; Social Sciences Citation Index

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Preprint Boettcher, A. (First author)DZNE* ; Zarucha, A.DZNE* ; Koebe, T.DZNE* ; Gaubert, M.DZNE* ; Höppner, A.DZNE* ; Fabel, K.DZNE* ; Altenstein, S.DZNE* ; Bartels, C.Extern* ; Bürger, K.DZNE* ; Dechent, P. ; Dobisch, L.DZNE* ; Ewers, M.DZNE* ; Fliessbach, K.DZNE* ; Freiesleben, S. D. ; Frommann, I.DZNE* ; Haynes, J. D. ; Janowitz, D. ; Kilimann, I.DZNE* ; Kleineidam, L.DZNE* ; Laske, C.DZNE* ; Maier, F. ; Metzger, C.DZNE* ; Munk, M. H.DZNE* ; Perneczky, R.DZNE* ; Peters, O.DZNE* ; Priller, J.DZNE* ; Rauchmann, B.-S. ; Roy, N.DZNE* ; Scheffler, K. ; Schneider, A.DZNE* ; Spottke, A.DZNE* ; Teipel, S. J.DZNE* ; Wiltfang, J.DZNE* ; Wolfsgruber, S.DZNE* ; Yakupov, R.DZNE* ; Duzel, E.DZNE* ; Jessen, F.DZNE* ; Röske, S.DZNE* ; Wagner, M.DZNE* ; Kempermann, G.DZNE* ; Wirth, M. (Last author)DZNE*
Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults
[10.1101/2021.09.15.460202]   Files BibTeX | EndNote: XML, Text | RIS

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