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| Home > Publications Database > A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy. |
| Home > Publications Database > A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy. |
| Journal Article | DZNE-2025-00755 |
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2025
Wiley
New York, NY
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Please use a persistent id in citations: doi:10.1002/mdc3.14348
Abstract: Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing.To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP.The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed.Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = -0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022).The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.
Keyword(s): Humans (MeSH) ; Supranuclear Palsy, Progressive: complications (MeSH) ; Supranuclear Palsy, Progressive: diagnosis (MeSH) ; Supranuclear Palsy, Progressive: psychology (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Cross-Sectional Studies (MeSH) ; Middle Aged (MeSH) ; Aged, 80 and over (MeSH) ; Longitudinal Studies (MeSH) ; Severity of Illness Index (MeSH) ; 4‐repeat tauopathies ; Progressive Supranuclear Palsy ; cognition ; depression ; quality of life
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